Effects of Coenzyme Q10 on Hemoglobin A1C, Serum Urea and Creatinine in Alloxan-Induced Type 1 Diabetic Rats

Coenzyme Q 10 is a natural antioxidant and free radicals scavenger. In the present study, we examined effect of coenzyme Q 10 on hemoglobin A 1C , serum urea and creatinine in alloxan-induced Type 1 diabetic rats. Thirty Sprage-Dawley male rats were divided into three groups randomly; group one as control, group two diabetic untreatment, and group three treatments with coenzyme Q 10 (15 mg/kg i.p daily), respectively . Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, animals were anaesthetized; blood samples were collected to measure the hemoglobin A 1C , serum glucose, urea and creatinine . Coenzyme Q 10 significantly decreased hemoglobin A 1C , serum glucose, urea and creatinine . Coenzyme Q 10 exerts beneficial effects on the hemoglobin A 1C and serum glucose in alloxan-induced type 1 diabetic rats.